Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.
Mutations in the human MECP2 gene cause Rett syndrome (RTT), a severe neurodevelopmental disorder that predominantly affects girls.Despite decades of work, the molecular function of MeCP2 is not fully understood.Here we report a systematic identification of MeCP2-interacting proteins in the mouse brain.In addition to transcription regulators, we fo